Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring stand-up comic Ira.

Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.

A miserable conman and his partner pose as Santa and his Little Helper to rob department stores on Christmas Eve. But they run into problems when the conman befriends a troubled kid.

Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.

Andy Stitzer has a pleasant life with a nice apartment and a job stamping invoices at an electronics store. But at age 40, there's one thing Andy hasn't done, and it's really bothering his sex-obsessed male co-workers: Andy is still a virgin. Determined to help Andy get laid, the guys make it their mission to de-virginize him. But it all seems hopeless until Andy meets small business owner Trish, a single mom.

Junior congressman Evan Baxter, whose wish is to "change the world" is heard by none other than God. When God appears with the perplexing request to build an ark, Evan is sure he is losing it.

Altruistic Jane finds herself facing her worst nightmare as her younger sister announces her engagement to the man Jane secretly adores.

When Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful Rachel Jansen, Peter is shocked to see not only Aldous Snow in Hawaii, but also Sarah Marshall.

A high school slacker who's rejected by every school he applies to opts to create his own institution of higher learning, the South Harmon Institute of Technology, on a rundown piece of property near his hometown.

After a disastrous first date for caterer Holly and network sports director Messer, all they have in common is a dislike for each other and their love for their goddaughter Sophie. But when they suddenly become all Sophie has in this world, Holly and Messer must set their differences aside. Juggling careers and social calendars, they'll have to find common ground while living under the same roof.

Follows Andy, who needs to hook up with a hottie, pronto, because he hasn't had sex in... well, forever - and his luck isn't the only thing that's hard. His equally horny teenage roommates also need it superbad, and with the help of their nerdy pal, McAnalovin' and his fake I.D., they may tap more than just a keg.

Two co-dependent high school seniors are forced to deal with separation anxiety after their plan to stage a booze-soaked party goes awry.

Jenna is a pregnant, unhappily married waitress in the deep south. She meets a newcomer to her town and falls into an unlikely relationship as a last attempt at happiness.

A romantically challenged morning show producer is reluctantly embroiled in a series of outrageous tests by her chauvinistic correspondent to prove his theories on relationships and help her find love. His clever ploys, however, lead to an unexpected result.

A stoner and his dealer are forced to go on the run from the police after the pothead witnesses a cop commit a murder.

In an effort to prevent family history from repeating itself, meddlesome mom Daphne Wilder attempts to set up her youngest daughter, Milly, with Mr. Right. Meanwhile, her other daughters try to keep their mom's good intentions under control.

When an elite assassin marries a beautiful computer whiz after a whirlwind romance, he gives up the gun and settles down with his new bride. That is, until he learns that someone from his past has put a contract out on his life.

Lifelong platonic friends Zack and Miri look to solve their respective cash-flow problems by making an adult film together. As the cameras roll, however, the duo begin to sense that they may have more feelings for each other than they previously thought.

Phil and Claire Foster fear that their mild-mannered relationship may be falling into a stale rut. During their weekly date night, their dinner reservation leads to their being mistaken for a couple of thieves—and now a number of unsavoury characters want Phil and Claire killed.

Two salesmen trash a company truck on an energy drink-fueled bender. Upon their arrest, the court gives them a choice: do hard time or spend 150 service hours with a mentorship program. After one day with the kids, however, jail doesn't look half bad.