Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.

Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring stand-up comic Ira.

A miserable conman and his partner pose as Santa and his Little Helper to rob department stores on Christmas Eve. But they run into problems when the conman befriends a troubled kid.

Lifelong platonic friends Zack and Miri look to solve their respective cash-flow problems by making an adult film together. As the cameras roll, however, the duo begin to sense that they may have more feelings for each other than they previously thought.

Junior congressman Evan Baxter, whose wish is to "change the world" is heard by none other than God. When God appears with the perplexing request to build an ark, Evan is sure he is losing it.

Altruistic Jane finds herself facing her worst nightmare as her younger sister announces her engagement to the man Jane secretly adores.

Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.

Forced to move to a boring backwater town, a teenager embarks on affairs with a teacher and a stoner classmate.

Follows Andy, who needs to hook up with a hottie, pronto, because he hasn't had sex in... well, forever - and his luck isn't the only thing that's hard. His equally horny teenage roommates also need it superbad, and with the help of their nerdy pal, McAnalovin' and his fake I.D., they may tap more than just a keg.

Two co-dependent high school seniors are forced to deal with separation anxiety after their plan to stage a booze-soaked party goes awry.

Andy Stitzer has a pleasant life with a nice apartment and a job stamping invoices at an electronics store. But at age 40, there's one thing Andy hasn't done, and it's really bothering his sex-obsessed male co-workers: Andy is still a virgin. Determined to help Andy get laid, the guys make it their mission to de-virginize him. But it all seems hopeless until Andy meets small business owner Trish, a single mom.

Jenna is a pregnant, unhappily married waitress in the deep south. She meets a newcomer to her town and falls into an unlikely relationship as a last attempt at happiness.

After standing in as best man for his longtime friend Carl Petersen, Randy Dupree loses his job, becomes a barfly and attaches himself to the newlywed couple almost permanently -- as their houseguest. But the longer Dupree camps out on their couch, the closer he gets to Carl's bride, Molly, leaving the frustrated groom wondering when his pal will be moving out.

Two salesmen trash a company truck on an energy drink-fueled bender. Upon their arrest, the court gives them a choice: do hard time or spend 150 service hours with a mentorship program. After one day with the kids, however, jail doesn't look half bad.

Advice columnist Dan Burns is an expert on relationships, but somehow struggles to succeed as a brother, a son and a single parent to three precocious daughters. Things get even more complicated when Dan finds out that the woman he falls in love with is actually his brother's new girlfriend.

A romantically challenged morning show producer is reluctantly embroiled in a series of outrageous tests by her chauvinistic correspondent to prove his theories on relationships and help her find love. His clever ploys, however, lead to an unexpected result.

When Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful Rachel Jansen, Peter is shocked to see not only Aldous Snow in Hawaii, but also Sarah Marshall.

Master chef Kate Armstrong runs her life and her kitchen with intimidating intensity. However, a recipe for disaster may be in the works when she becomes the guardian of her young niece while crossing forks with the brash sous-chef who just joined her staff. Though romance blooms in the face of rivalry, Kate needs to look outside the kitchen to find true happiness.

In an effort to prevent family history from repeating itself, meddlesome mom Daphne Wilder attempts to set up her youngest daughter, Milly, with Mr. Right. Meanwhile, her other daughters try to keep their mom's good intentions under control.

Noah, is not your typical entertain-the-kids-no-matter-how-boring-it-is kind of sitter. He's reluctant to take a sitting gig; he'd rather, well, be doing anything else, especially if it involves slacking. When Noah is watching the neighbor's kid he gets a booty call from his girlfriend in the city. To hook up with her, Noah takes to the streets, but his urban adventure spins out of control as he finds himself on the run from a maniacal drug lord.